Cross-linked Hyaluronic Acid Monophasic Deep Filler

1. Core Definition & Product Positioning

Cross-linked Hyaluronic Acid Deep Monophase is a high-crosslinking, monophasic gel dermal filler designed for deep dermal to superficial subcutaneous injection. The term "Deep" denotes its application for deep volume supplementation, and "Monophase" refers to its homogeneous gel structure without free hyaluronic acid or particle stratification. It is mainly used for correcting severe wrinkles and replenishing facial deep volume, providing stable support and long-lasting aesthetic effects with minimal displacement risk.

2. Key Physicochemical Properties

This product has a high crosslinking degree of 85% to 90%, ensuring strong structural stability and support capacity. The hyaluronic acid concentration ranges from 20 to 24 mg/mL, which balances injection smoothness and volumizing effect. Its raw material is non-animal derived microbial fermentation hyaluronic acid, featuring excellent biocompatibility and low allergenicity. It adopts advanced crosslinking technologies such as BDDE, VYCROSS or E-brid, with crosslinking agent residue less than 1 ppm in line with medical standards. The elastic modulus (G′) is relatively high, and the viscous modulus (G″) is moderate, making it easy to inject while maintaining shape. The in vivo half-life is 10 to 18 months, varying with individual metabolism, injection site and dosage.

3. Core Advantages

Its homogeneous monophasic structure enables seamless integration with deep skin tissues, avoiding post-injection unevenness or particle sensation. The high crosslinking degree endows it with strong cohesion and anti-degradation ability, ensuring long-lasting volume retention and stable shaping without easy displacement. It has low water absorption, resulting in mild postoperative swelling and fast recovery. Most products are added with 0.3% lidocaine to reduce injection pain, improving patient comfort. Meanwhile, it can moderately enhance skin hydration while supplementing volume, achieving a natural and plump skin state.

4. Typical Application Scenarios

For wrinkle correction, it is effective in improving severe static wrinkles such as deep nasolabial folds, heavy marionette lines and forehead deep wrinkles. In terms of volume supplementation, it can fill deep facial depressions including temporal fossa, cheek deep atrophy and nasal base depression. It is also suitable for mild facial contour shaping, such as apple muscle lifting, chin volume enhancement and jawline refinement, meeting the needs of clients for natural deep volumizing and contour improvement.

5. Indications & Contraindications

Indications

It is applicable to adults with severe facial static wrinkles, deep volume loss, and those seeking long-lasting deep dermal filling with an efficacy duration of 10 to 18 months.

Contraindications

It is contraindicated for individuals allergic to hyaluronic acid, lidocaine or crosslinking agents, patients with injection site infection, inflammation, ulceration or coagulation disorders. Pregnant or lactating women should use it with caution.

6. Injection & Safety Tips

The injection layer should be accurately delivered to the deep dermis or superficial subcutaneous tissue; avoid superficial injection which may cause nodularity, or overly deep injection that may damage blood vessels and nerves. The recommended injection technique is fan-shaped or radial injection with small single-point dosage and multi-layer delivery to ensure uniform distribution. For post-operation care, avoid rubbing, pressing or massaging the injection site within 24 hours, keep the site clean and dry, and refrain from high-temperature environments, intense exercise and alcohol consumption for 1 week.