Cross-linked Hyaluronic Acid Monophasic Dermal Filler

1. Core Definition & Product Positioning

Cross-linked Hyaluronic Acid Derm Monophase refers to a mid-crosslinking, monophasic gel dermal filler designed for intradermal mid-layer injection. The term "Derm" indicates its application targeting the dermis, while "Monophase" means it has a homogeneous, particle-free gel structure without free hyaluronic acid separation. It is mainly used for moderate wrinkle correction and mild facial volume supplementation, delivering natural, smooth aesthetic results with low risk of nodularity or unevenness.

2. Key Physicochemical Properties

This product features a moderate crosslinking degree ranging from 60% to 75%, which balances support and flexibility effectively. The hyaluronic acid concentration is between 20 and 24 mg/mL, an optimal range for intradermal mid-layer injection. Its raw material is non-animal derived microbial fermentation hyaluronic acid, ensuring high biocompatibility. The crosslinking agent adopted is BDDE (1,4-Butanediol diglycidyl ether), with a residue content of less than 1 ppm that meets medical standards. The elastic modulus (G′) is in the medium range, making it suitable for dynamic facial areas such as nasolabial folds. The in vivo half-life is 6 to 12 months, which varies depending on individual metabolism and injection site.

3. Core Advantages

It boasts a homogeneous texture; the monophasic gel structure ensures seamless integration with skin tissue, avoiding post-injection lumpiness and achieving a natural look. The smooth gel consistency enables controllable injection, allowing easy pushing and precise dosage control, which reduces tissue trauma during operation. The risk of side effects is low-non-animal derived raw materials minimize immunogenic reactions, and mild redness and bruising usually subside within 3 to 5 days. Additionally, it offers dual effects: while filling moderate wrinkles, it also replenishes skin moisture and improves skin elasticity.

4. Typical Application Scenarios

In terms of wrinkle correction, it is effective in improving moderate static wrinkles, such as nasolabial folds, marionette lines, and cheek fine lines. For mild volume replenishment, it can fill slight cheek depressions, lip line wrinkles, and temple mild atrophy. It also contributes to skin texture improvement by enhancing skin hydration and firmness, making it suitable for clients pursuing natural, non-exaggerated aesthetic outcomes.

5. Indications & Contraindications

Indications

It is applicable to adults with moderate facial static wrinkles and mild volume loss, as well as clients seeking natural dermal filling with an efficacy duration of 6 to 12 months.

Contraindications

It is contraindicated for individuals allergic to hyaluronic acid or lidocaine, patients with injection site infection, inflammation, or coagulation disorders. Pregnant or lactating women should use it with caution.

6. Injection & Safety Tips

The injection layer must be accurately delivered to the intradermal mid-layer; avoid superficial injection which may cause skin ridges, or deep injection that reduces the filling effect. The recommended injection technique is to adopt linear or fanned injection with small single-point dosage, avoiding over-correction. For post-operation care, do not rub the injection site within 24 hours, and refrain from high-temperature environments such as saunas for 1 week.