20+120mg Artemether and Lumefantrine Tablets

Mechanism of action: Artemether and Lumefantrine exert synergistic antimalarial effect, Artemether rapidly kills erythrocytic stage plasmodium by damaging plasmodium mitochondrial membrane structure; Lumefantrine inhibits plasmodium nucleic acid synthesis and metabolic process, prolongs antimalarial efficacy and reduces drug resistance risk. Oral absorption is enhanced with fatty food, peak plasma concentration reached in 4-8 hours, long duration of action.

Indications: Used for the treatment of acute uncomplicated falciparum malaria in adults and children over 5 kg; also effective for vivax malaria, clinical first-line antimalarial medicine.

Usage and dosage: Oral administration, take with food, milk or fatty food to increase absorption. Adult and children over 35 kg: 4 tablets once, twice a day, for 3 consecutive days, total 24 tablets for a course of treatment. Pediatric (by body weight): 5-14kg:1 tablet once;15-24kg:2 tablets once;25-34kg:3 tablets once, twice a day, for 3 consecutive days. Strictly follow weight-based dosage, do not change dose at will.

Contraindications: Contraindicated in patients allergic to this product, artemether, lumefantrine and any excipient of this preparation.

Cautious population: Use with caution in patients with severe hepatic and renal insufficiency; use with caution in patients with cardiovascular disease, QT interval prolongation and bradycardia; pregnant and lactating women use with caution after weighing benefits and risks; elderly patients with poor physical condition use with caution; infants under 5 kg are not recommended to use.

Adverse reactions: Mild and reversible adverse reactions, common nausea, vomiting, abdominal pain, diarrhea, anorexia and other gastrointestinal discomfort; occasional dizziness, headache, fatigue, insomnia and asthenia; rare rash, pruritus, arthralgia and myalgia; a small number of patients have mild QT interval prolongation, which recovers after drug withdrawal, no cinchonism reaction.

Notes: This product is only for acute malaria treatment, not for malaria prevention; effective for erythrocytic stage plasmodium only, primaquine combination can be considered if needed to prevent malaria recurrence; avoid combined use with drugs that prolong QT interval to reduce arrhythmia risk; swallow whole with water, do not chew or crush; store in cool and dry place protected from light.