Diclofenac Sodium & Paracetamol Tablets

Mechanism of action: A compound preparation combining two potent antipyretic and analgesic ingredients with synergistic effect. Diclofenac Sodium strongly inhibits cyclooxygenase (COX-1/COX-2) to block prostaglandin synthesis, exerting powerful anti-inflammatory and analgesic effects; Paracetamol acts on the hypothalamic thermoregulatory center to reduce fever and relieve pain, with mild gastrointestinal irritation. The combination enhances antipyretic, analgesic and anti-inflammatory efficacy, reduces single drug dosage and adverse reaction risk, and has faster onset and longer duration of action.

Indications: Relief of moderate to severe pain including rheumatoid arthritis, osteoarthritis, ankylosing spondylitis induced joint pain, swelling and stiffness; treatment of acute musculoskeletal pain (myalgia, neuralgia, lumbago, backache, sprain, contusion); relief of headache, toothache, dysmenorrhea, postoperative pain and cancer pain adjuvant therapy; antipyretic for fever caused by cold, influenza and various infectious diseases; anti-inflammatory and pain relief for soft tissue inflammation, tenosynovitis and bursitis.

Usage and dosage: Oral administration, take with warm water after meals to reduce gastrointestinal irritation. Adult: 1 tablet once a time, 2~3 times a day; maximum daily dose ≤ 3 tablets. The course of treatment for pain is 3~7 days, for anti-inflammatory is 7~14 days; adjust dosage according to symptom severity under medical guidance.

Contraindications: Contraindicated in patients allergic to this product, diclofenac sodium, paracetamol, NSAIDs and any excipients; contraindicated in patients with active peptic ulcer, gastrointestinal bleeding and perforation history; contraindicated in severe hepatic/renal/cardiac insufficiency patients; contraindicated in pregnant women (third trimester), lactating women and minors under 16 years old; contraindicated in patients with severe blood system diseases and coagulation dysfunction.

Cautious population: Use with caution in patients with mild to moderate hepatic/renal insufficiency (monitor liver/kidney function regularly, reduce dosage); use with caution in gastrointestinal disease history patients (avoid long-term use); use with caution in hypertension, heart failure and edema patients (may cause fluid retention); elderly patients with reduced organ function take the minimum effective dose; allergic constitution patients use under close observation; avoid combined use with other NSAIDs, antipyretic analgesics and alcohol to prevent liver injury and gastrointestinal bleeding.

Adverse reactions: Common reactions: Mild gastrointestinal discomfort (nausea, abdominal distension, loose stool), dizziness, headache and fatigue; symptoms relieve after meals or dosage reduction. Rare reactions: Gastrointestinal erosion, mild bleeding (melena, hematemesis) in long-term use; transient elevation of transaminase and renal function indexes; skin rash, pruritus and other allergic reactions; peripheral edema, hypertension and palpitations in individual patients. Severe adverse reactions: Extremely rare severe allergic shock, severe liver/kidney damage and peptic ulcer perforation; adverse reactions are mild and controllable with standard dosage, significantly lower than single high-dose diclofenac sodium.

Notes: Take after meals strictly to reduce gastrointestinal irritation; do not take with alcohol, aspirin and other NSAIDs to avoid overdose and adverse reactions; long-term medication should monitor liver function, renal function and blood routine regularly; stop medication immediately and consult a doctor if gastrointestinal bleeding, rash, jaundice or oliguria occurs; store in a cool dry place, avoid light and high temperature, seal for preservation;