Ferrous Sulfate and Folic Acid Tablets

1.Mechanism of action:

A compound preparation of iron and folic acid with synergistic effect. Ferrous sulfate provides elemental iron, which is the core raw material for hemoglobin synthesis and participates in erythrocyte formation and oxygen transport; Folic acid is a water-soluble B vitamin, participates in the synthesis and metabolism of nucleic acid and protein, promotes the maturation and division of megaloblasts, corrects megaloblastic anemia. Iron deficiency combined with folic acid deficiency is common in clinical anemia, the compound preparation can supplement two essential nutrients at the same time and improve the curative effect significantly.

2.Indications:

Prevention and treatment of iron deficiency anemia complicated with folic acid deficiency; iron and folic acid supplement for pregnant women, lactating women, postpartum women and adolescent girls; adjuvant treatment of anemia caused by malnutrition, chronic mild blood loss and megaloblastic anemia; routine nutritional supplement for women during pregnancy to prevent fetal neural tube malformation and maternal anemia.

3.Usage and dosage:

Oral administration, take after meals with warm water to reduce gastrointestinal irritation, swallow whole without chewing. Adult: 1~2 tablets once, 3 times a day. Pregnant and lactating women: 2 tablets once, 3 times a day. The course of treatment is 3~6 months until hemoglobin and serum ferritin return to normal levels, and continue medication for 1~2 months to replenish iron stores. Pediatric (over 4 years old): 1 tablet once, 2 times a day, adjust dosage according to age and weight under medical guidance.

4.Contraindications:

Contraindicated in patients allergic to this product, ferrous salts, folic acid and any excipients of the preparation; contraindicated in patients with iron overload, hemochromatosis, hemosiderosis; contraindicated in patients with hemolytic anemia (autoimmune hemolytic anemia, sickle cell anemia); contraindicated in patients with untreated pernicious anemia (needs vitamin B12 supplementation); contraindicated in patients with severe renal insufficiency and acute liver failure.

5.Cautious population:

Use with caution in patients with mild to moderate hepatic and renal insufficiency (monitor liver and kidney function regularly); use with caution in patients with peptic ulcer, gastritis and gastrointestinal bleeding history (reduce irritation by taking after meals); use with caution in patients with acute infection and inflammation; elderly patients with reduced gastrointestinal function use with small dose and observe reaction; infants and young children under 4 years old use under strict medical guidance; patients receiving antiepileptic drugs and methotrexate use with caution (affect folic acid metabolism).

6.Adverse reactions:

Mild and mild adverse reactions, gastrointestinal symptoms are the most common: nausea, vomiting, abdominal distension, abdominal pain, diarrhea and constipation, which can be relieved by taking after meals; black stool is a normal phenomenon (caused by iron ion oxidation in intestinal tract), which is not gastrointestinal bleeding and disappears after drug withdrawal; occasional bitter taste, metallic taste in the mouth and loss of appetite; rare allergic reactions (skin rash, pruritus), folic acid overdose may cause nausea, bloating and yellow urine (water-soluble, excess folic acid is excreted in urine); long-term large-dose use may cause iron overload and elevated serum iron, no serious adverse reactions.

7.Notes:

Take after meals to reduce gastrointestinal irritation, avoid taking on an empty stomach; take with vitamin C to promote iron absorption, improve bioavailability; avoid taking with tea, coffee, milk, eggs and antacids at the same time (tannic acid and calcium ions combine with iron to reduce absorption); do not take with tetracycline antibiotics and levodopa (mutual inhibition of absorption); complete the full course of treatment to replenish iron and folic acid stores and prevent anemia recurrence; regular monitoring of hemoglobin, serum iron, ferritin and folic acid levels during medication; yellow urine caused by folic acid is normal and does not affect medication; store in a cool and dry place, avoid light and high temperature, keep out of reach of children to prevent accidental ingestion.